Unknown

Dataset Information

0

Tumor Microenvironment and Immunotherapy Response in Head and Neck Cancer.

ABSTRACT: The tumor microenvironment (TME) encompasses cellular and non-cellular components which play an important role in tumor evolution, invasion, and metastasis. A complicated interplay between tumor cells and adjacent TME cells, such as stromal cells, immune cells, inflammatory cells, and cytokines, leads to severe immunosuppression and the proliferation of cancer cells in several solid tumors. An immunosuppressive TME has a significant impact on treatment resistance and may guide response to immunotherapy. In head and neck cancer (HNC), immunotherapeutic drugs have been incorporated in everyday clinical practice. However, despite an exceptional rate of durable responses, only a low percentage of patients respond. In this review, we will focus on the complex interactions occurring in this dynamic system, the TME, which orchestrate key events that lead to tumor progression, immune escape, and resistance. Furthermore, we will summarize current clinical trials that depict the TME as a potential therapeutic target for improved patient selection.

SUBMITTER: Economopoulou P 

PROVIDER: S-EPMC7696050 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Tumor Microenvironment and Immunotherapy Response in Head and Neck Cancer.

Economopoulou Panagiota P   Kotsantis Ioannis I   Psyrri Amanda A  

Cancers 20201115 11

The tumor microenvironment (TME) encompasses cellular and non-cellular components which play an important role in tumor evolution, invasion, and metastasis. A complicated interplay between tumor cells and adjacent TME cells, such as stromal cells, immune cells, inflammatory cells, and cytokines, leads to severe immunosuppression and the proliferation of cancer cells in several solid tumors. An immunosuppressive TME has a significant impact on treatment resistance and may guide response to immuno  ...[more]

Similar Datasets

Unknown The causal impact of complement C3d receptor 2 on head and neck cancer microenvironment and its implications for immunotherapy response prediction.
| S-EPMC11016721 | biostudies-literature
Unknown Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck Cancer.
| S-EPMC9161438 | biostudies-literature
Unknown Tumor cell HLA class I expression and pathologic response following neoadjuvant immunotherapy for newly diagnosed head and neck cancer.
| S-EPMC9974754 | biostudies-literature
Other Spatially resolving the tumour microenvironment of head and neck cancer to discover novel predictive biomarkers of immunotherapy response
2024-07-30 | GSE255939 | GEO
Unknown Comprehensive characterization of the tumor microenvironment for assessing immunotherapy outcome in patients with head and neck squamous cell carcinoma.
| S-EPMC7746351 | biostudies-literature
Unknown Immunotherapy in Head and Neck Squamous Cell Cancer.
| S-EPMC6222190 | biostudies-literature
Unknown Immunology and Immunotherapy of Head and Neck Cancer.
| S-EPMC4586169 | biostudies-literature
Unknown Tumor microenvironment characterization in head and neck cancer identifies prognostic and immunotherapeutically relevant gene signatures.
| S-EPMC7341839 | biostudies-literature
Unknown Tumor Immunology and Immunotherapy for Head and Neck Squamous Cell Carcinoma.
| S-EPMC6728550 | biostudies-literature
Transcriptomics Immunostimulatory cancer-associated fibroblast subpopulations can predict immunotherapy response in head and neck cancer
2022-03-16 | GSE195832 | GEO