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Multicentric Atrial Strain COmparison between Two Different Modalities: MASCOT HIT Study.

ABSTRACT: Two methods are currently available for left atrial (LA) strain measurement by speckle tracking echocardiography, with two different reference timings for starting the analysis: QRS (QRS-LASr) and P wave (P-LASr). The aim of MASCOT HIT study was to define which of the two was more reproducible, more feasible, and less time consuming. In 26 expert centers, LA strain was analyzed by two different echocardiographers (young vs senior) in a blinded fashion. The study population included: healthy subjects, patients with arterial hypertension or aortic stenosis (LA pressure overload, group 2) and patients with mitral regurgitation or heart failure (LA volume-pressure overload, group 3). Difference between the inter-correlation coefficient (ICC) by the two echocardiographers using the two techniques, feasibility and analysis time of both methods were analyzed. A total of 938 subjects were included: 309 controls, 333 patients in group 2, and 296 patients in group 3. The ICC was comparable between QRS-LASr (0.93) and P-LASr (0.90). The young echocardiographers calculated QRS-LASr in 90% of cases, the expert ones in 95%. The feasibility of P-LASr was 85% by young echocardiographers and 88% by senior ones. QRS-LASr young median time was 110 s (interquartile range, IR, 78-149) vs senior 110 s (IR 78-155); for P-LASr, 120 s (IR 80-165) and 120 s (IR 90-161), respectively. LA strain was feasible in the majority of patients with similar reproducibility for both methods. QRS complex guaranteed a slightly higher feasibility and a lower time wasting compared to the use of P wave as the reference.

SUBMITTER: Cameli M

PROVIDER: S-EPMC7696899 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Multicentric Atrial Strain COmparison between Two Different Modalities: MASCOT HIT Study.

Cameli Matteo M Miglioranza Marcelo Haertel MH Magne Julien J Mandoli Giulia Elena GE Benfari Giovanni G Ancona Roberta R Sibilio Gerolamo G Reskovic Luksic Vlatka V Dejan Dosen D Griseli Leonardo L Van De Heyning Caroline M CM Mortelmans Philippe P Michalski Blazej B Kupczynska Karolina K Di Giannuario Giovanna G Devito Fiorella F Dulgheru Raluca R Ilardi Federica F Salustri Alessandro A Abushahba Galal G Morrone Doralisa D Fabiani Iacopo I Penicka Martin M Katbeh Asim A Sammarco Giuseppe G Esposito Roberta R Santoro Ciro C Pastore Maria Concetta MC Comenale Pinto Salvatore S Kalinin Artem A Pičkure Žanna Ž Ažman Juvan Katja K Zupan Mežnar Anja A Coisne Augustine A Coppin Amandine A Opris Mihaela Maria MM Nistor Dan Octavian DO Paakkanen Riitta R Biering-Sørensen Tor T Olsen Flemming Javier FJ Lapinskas Tomas T Vaškelyté Jolanta Justina JJ Galian-Gay Laura L Casas Guillem G Motoc Andreea Iulia AI Papadopoulos Constantinos Hristou CH Loizos Savvas S Ágoston Gergely G Szabó Istvan I Hristova Krasimira K Tsonev Svetlin Netkov SN Galli Elena E Vinereanu Dragos D Mihaila Baldea Sorina S Muraru Denisa D Mondillo Sergio S Donal Erwan E Galderisi Maurizio M Cosyns Bernard B Edvardsen Thor T Popescu Bogdan A BA

Diagnostics (Basel, Switzerland) 20201113 11

Two methods are currently available for left atrial (LA) strain measurement by speckle tracking echocardiography, with two different reference timings for starting the analysis: QRS (QRS-LASr) and P wave (P-LASr). The aim of MASCOT HIT study was to define which of the two was more reproducible, more feasible, and less time consuming. In 26 expert centers, LA strain was analyzed by two different echocardiographers (young vs senior) in a blinded fashion. The study population included: healthy subj ...[more]

PMID: 33202837

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Project description:BackgroundDurations of exclusive breastfeeding (EBF) and predominant breastfeeding (PBF) from two different assessments, among the same mother-infant population, were investigated to determine the degree to which the assessments yielded overlapping results.MethodsThirty Ugandan mother-infant pairs were followed up weekly from birth to three months of age with weekly short-time feeding recall: the 24-hour recall asked prior to the 1-week recall. In addition, at week 6 and 12 dietary recalls since-birth were conducted. Variables for the duration of EBF and PBF were created from the short-time feeding recalls and the dietary recalls since-birth, respectively. Mean durations of EBF and PBF from the two assessments were compared with Kaplan Meier analysis at week 6 and 12. Reproducibility of dietary recall instruments was also assessed.ResultsAt six weeks postpartum the mean durations of EBF were 0.50 weeks (95% CI: 0, 1.02) according to the weekly short-time recalls and 1.51 weeks (95% CI: 0.66, 2.35) according to the recall since-birth (Mantel-Cox test, p = 0.049). The mean durations of PBF were 4.07 weeks (95% CI: 3.38, 4.77) according to the frequent short-time recalls and 4.50 weeks (95% CI: 3.93, 5.07) according to the recall since-birth, (Mantel-Cox-test, p = 0.82). At twelve weeks the mean durations of EBF were 0.5 weeks (95% CI: 0, 1.1) according to the weekly short-time recalls and 1.4 weeks (95% CI: 0.1, 2.7) according to the recall since-birth (Mantel-Cox-test, p = 0.15). The mean durations of PBF were 5.2 weeks (95% CI: 3.9, 6.5) according to the weekly short-time recalls and 6.6 weeks (95% CI: 5.4, 7.8) according to recall since-birth (Mantel-Cox-test, p = 0.20). Reports of feeding categories and early feeding practices showed high reproducibility.ConclusionComparing duration of EBF and PBF in this group of mother-infant pairs showed overlapping results from the weekly short-time assessment and the recall since-birth at twelve weeks, with the latter yielding slightly longer duration of the respective feeding modalities. The retrospective recall since-birth could be assessed as a cost-reducing tool compared to the frequent follow-up addressing duration of respective infant feeding modalities for evaluation of programmes promoting safer infant feeding practices.Trial registrationThe study was part of formative studies for the ongoing study PROMISE EBF registered at http://clinicaltrials.gov, NCT00397150.

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Multicentric Atrial Strain COmparison between Two Different Modalities: MASCOT HIT Study.

Publications

Multicentric Atrial Strain COmparison between Two Different Modalities: MASCOT HIT Study.

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