Ontology highlight
ABSTRACT:
SUBMITTER: Greco C
PROVIDER: S-EPMC7696985 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Greco Chiara C Catania Rosa R Balacco Dario Leonardo DL Taresco Vincenzo V Musumeci Francesca F Alexander Cameron C Huett Alan A Schenone Silvia S
Molecules (Basel, Switzerland) 20201116 22
Pyrazolo[3,4-<i>d</i>]pyrimidines represent an important class of heterocyclic compounds well-known for their anticancer activity exerted by the inhibition of eukaryotic protein kinases. Recently, pyrazolo[3,4-<i>d</i>]pyrimidines have become increasingly attractive for their potential antimicrobial properties. Here, we explored the activity of a library of in-house pyrazolo[3,4-<i>d</i>]pyrimidines, targeting human protein kinases, against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i ...[more]