Ontology highlight
ABSTRACT:
SUBMITTER: Panahipour L
PROVIDER: S-EPMC7696998 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Panahipour Layla L Kargarpour Zahra Z Laggner Maria M Mildner Michael M Ankersmit Hendrik J HJ Gruber Reinhard R
International journal of molecular sciences 20201113 22
Osteoclastogenesis required for bone remodeling is also a key pathologic mechanism of inflammatory osteolysis being controlled by paracrine factors released from dying cells. The secretome of irradiated, dying peripheral blood mononuclear cells (PBMCs) has a major impact on the differentiation of myeloid cells into dendritic cells, and macrophage polarization. The impact on osteoclastogenesis, however, has not been reported. For this aim, we used murine bone marrow macrophages exposed to RANKL a ...[more]