Ontology highlight
ABSTRACT:
SUBMITTER: Guajardo L
PROVIDER: S-EPMC7697002 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Guajardo Laura L Aguilar Rodrigo R Bustos Fernando J FJ Nardocci Gino G Gutiérrez Rodrigo A RA van Zundert Brigitte B Montecino Martin M
International journal of molecular sciences 20201111 22
Ezh2 is a catalytic subunit of the polycomb repressive complex 2 (PRC2) which mediates epigenetic gene silencing through depositing the mark histone H3 lysine 27 trimethylation (H3K27me3) at target genomic sequences. Previous studies have demonstrated that Enhancer of Zeste Homolog 2 (Ezh2) was differentially expressed during maturation of hippocampal neurons; in immature neurons, Ezh2 was abundantly expressed, whereas in mature neurons the expression Ezh2 was significantly reduced. Here, we rep ...[more]