Ontology highlight
ABSTRACT:
SUBMITTER: Gurnari C
PROVIDER: S-EPMC7697160 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Gurnari Carmelo C Pagliuca Simona S Visconte Valeria V
International journal of molecular sciences 20201112 22
Acute myeloid leukemia (AML) is a clonal hematopoietic disorder characterized by abnormal proliferation, lack of cellular differentiation, and infiltration of bone marrow, peripheral blood, or other organs. Induction failure and in general resistance to chemotherapeutic agents represent a hindrance for improving survival outcomes in AML. Here, we review the latest insights in AML biology concerning refractoriness to therapies with a specific focus on cytarabine and daunorubicin which still repre ...[more]