Exploring the Role of Contactins across Psychological, Psychiatric and Cardiometabolic Traits within UK Biobank.
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ABSTRACT:
SUBMITTER: Morris J
PROVIDER: S-EPMC7697406 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Exploring the Role of Contactins across Psychological, Psychiatric and Cardiometabolic Traits within UK Biobank.
Morris Julia J Leung Soddy Sau Yu SSY Bailey Mark E S MES Cullen Breda B Ferguson Amy A Graham Nicholas N Johnston Keira J A KJA Lyall Donald M DM Lyall Laura M LM Ward Joey J Smith Daniel J DJ Strawbridge Rona J RJ
Genes 20201110 11
Individuals with severe mental illness have an increased risk of cardiometabolic diseases compared to the general population. Shared risk factors and medication effects explain part of this excess risk; however, there is growing evidence to suggest that shared biology (including genetic variation) is likely to contribute to comorbidity between mental and physical illness. Contactins are a family of genes involved in development of the nervous system and implicated, though genome-wide association ...[more]
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