Ontology highlight
ABSTRACT:
SUBMITTER: Vrancianu CO
PROVIDER: S-EPMC7697847 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Vrancianu Corneliu Ovidiu CO Gheorghe Irina I Dobre Elena-Georgiana EG Barbu Ilda Czobor IC Cristian Roxana Elena RE Popa Marcela M Lee Sang Hee SH Limban Carmen C Vlad Ilinca Margareta IM Chifiriuc Mariana Carmen MC
International journal of molecular sciences 20201112 22
Since the discovery of penicillin by Alexander Fleming in 1929 as a therapeutic agent against staphylococci, β-lactam antibiotics (BLAs) remained the most successful antibiotic classes against the majority of bacterial strains, reaching a percentage of 65% of all medical prescriptions. Unfortunately, the emergence and diversification of β-lactamases pose indefinite health issues, limiting the clinical effectiveness of all current BLAs. One solution is to develop β-lactamase inhibitors (BLIs) cap ...[more]