Evaluation of a visual interpretation method for tau-PET with ¹⁸F-flortaucipir.

ABSTRACT:

Introduction

Positron emission tomography targeting tau (tau-PET) is a promising diagnostic tool for the identification of Alzheimer's disease (AD). Currently available data rely on quantitative measures, and a visual interpretation method, critical for clinical translation, is needed.

Methods

We developed a visual interpretation method for ¹⁸F-flortaucipir tau-PET and tested it on 274 individuals (cognitively normal controls, patients with mild cognitive impairment [MCI], AD dementia, and non-AD diagnoses). Two readers interpreted ¹⁸F-flortaucipir PET using two complementary indices: a global visual score and a visual distribution pattern.

Results

Global visual scores were reliable, correlated with global cortical ¹⁸F-flortaucipir sta

SUBMITTER: Sonni I 

PROVIDER: S-EPMC7699207 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature