Ontology highlight
ABSTRACT:
SUBMITTER: Mostazo MGC
PROVIDER: S-EPMC7699488 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Mostazo Miriam G Contreras MGC Kurrle Nina N Casado Marta M Fuhrmann Dominik D Alshamleh Islam I Häupl Björn B Martín-Sanz Paloma P Brüne Bernhard B Serve Hubert H Schwalbe Harald H Schnütgen Frank F Marin Silvia S Cascante Marta M
Cancers 20201119 11
Tyrosine kinase inhibitors (TKIs) are currently the standard chemotherapeutic agents for the treatment of chronic myeloid leukemia (CML). However, due to TKI resistance acquisition in CML patients, identification of new vulnerabilities is urgently required for a sustained response to therapy. In this study, we have investigated metabolic reprogramming induced by TKIs independent of BCR-ABL1 alterations. Proteomics and metabolomics profiling of imatinib-resistant CML cells (ImaR) was performed. K ...[more]