Ontology highlight
ABSTRACT:
SUBMITTER: Savastano A
PROVIDER: S-EPMC7699647 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Savastano Adriana A Ibáñez de Opakua Alain A Rankovic Marija M Zweckstetter Markus M
Nature communications 20201127 1
The etiologic agent of the Covid-19 pandemic is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The viral membrane of SARS-CoV-2 surrounds a helical nucleocapsid in which the viral genome is encapsulated by the nucleocapsid protein. The nucleocapsid protein of SARS-CoV-2 is produced at high levels within infected cells, enhances the efficiency of viral RNA transcription, and is essential for viral replication. Here, we show that RNA induces cooperative liquid-liquid phase separ ...[more]