Effect of High-Dose vs Standard-Dose Vitamin D₃ Supplementation on Body Composition among Patients with Advanced or Metastatic Colorectal Cancer: A Randomized Trial.

ABSTRACT: Skeletal muscle and adipose tissue express the vitamin D receptor and may be a mechanism through which vitamin D supplementation slows cancer progression and reduces cancer death. In this exploratory analysis of a double-blind, multicenter, randomized phase II clinical trial, 105 patients with advanced or metastatic colorectal cancer who were receiving chemotherapy were randomized to either high-dose vitamin D₃ (4000 IU) or standard-dose (400 IU) vitamin D₃. Body composition was measured with abdominal computed tomography at enrollment (baseline) and after cycle 8 of chemotherapy (16 weeks). As compared with standard-dose vitamin D₃, high-dose vitamin D₃ did not significantly change body weight [-0.7 kg; (95% CI: -3.5, 2.0)], body mass index [-0.

SUBMITTER: Brown JC 

PROVIDER: S-EPMC7699725 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature