Scopolin Attenuates Osteoporotic Bone Loss in Ovariectomized Mice.
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ABSTRACT:
SUBMITTER: Park E
PROVIDER: S-EPMC7699886 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
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Scopolin Attenuates Osteoporotic Bone Loss in Ovariectomized Mice.
Park Eunkuk E Kim Jeonghyun J Jin Hyun-Seok HS Choi Chun Whan CW Choi Tae Hyun TH Choi Sangho S Huh Dam D Jeong Seon-Yong SY
Nutrients 20201120 11
Bone remodeling is a renewal process regulated by bone synthesis (osteoblasts) and bone destruction (osteoclasts). A previous study demonstrated that <i>Lycii radicis</i> cortex (LRC) extract inhibited ovariectomized (OVX)-induced bone loss in mice. This study investigated the anti-osteoporotic effects of bioactive constituent(s) from the LRC extract. The effective compound(s) were screened, and a single compound, scopolin, which acts as a phytoalexin, was chosen as a candidate component. Scopol ...[more]
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