Ontology highlight
ABSTRACT:
SUBMITTER: Piipponen M
PROVIDER: S-EPMC7699912 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Piipponen Minna M Li Dongqing D Landén Ning Xu NX
International journal of molecular sciences 20201120 22
As the most dominant cell type in the skin, keratinocytes play critical roles in wound repair not only as structural cells but also exerting important immune functions. This review focuses on the communications between keratinocytes and immune cells in wound healing, which are mediated by various cytokines, chemokines, and extracellular vesicles. Keratinocytes can also directly interact with T cells via antigen presentation. Moreover, keratinocytes produce antimicrobial peptides that can directl ...[more]