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Cytotoxic and Antiproliferative Effects of Diarylheptanoids Isolated from Curcuma comosa Rhizomes on Leukaemic Cells.

ABSTRACT: Curcuma comosa belongs to the Zingiberaceae family. In this study, two natural compounds were isolated from C. comosa, and their structures were determined using nuclear magnetic resonance. The isolated compounds were identified as 7-(3,4-dihydroxyphenyl)-5-hydroxy-1-phenyl-(1E)-1-heptene (1) and trans-1,7-diphenyl-5-hydroxy-1-heptene (2). Compound 1 showed the strongest cytotoxicity effect against HL-60 cells, while its antioxidant and anti-inflammatory properties were stronger than those of compound 2. Compound 1 proved to be a potent antioxidant, compared to ascorbic acid. Neither compounds had any effect on red blood cell haemolysis. Furthermore, compound 1 significantly decreased Wilms' tumour 1 protein expression and cell proliferation in KG-1a cells. Compound 1 decreased the WT1 protein levels in a time- and dose- dependent manner. Compound 1 suppressed cell cycle at the S phase. In conclusion, compound 1 has a promising chemotherapeutic potential against leukaemia.

SUBMITTER: Viriyaadhammaa N 

PROVIDER: S-EPMC7700379 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Cytotoxic and Antiproliferative Effects of Diarylheptanoids Isolated from <i>Curcuma comosa</i> Rhizomes on Leukaemic Cells.

Viriyaadhammaa Natsima N   Saiai Aroonchai A   Neimkhum Waranya W   Nirachonkul Wariya W   Chaiyana Wantida W   Chiampanichayakul Sawitree S   Tima Singkome S   Usuki Toyonobu T   Duangmano Suwit S   Anuchapreeda Songyot S  

Molecules (Basel, Switzerland) 20201123 22

<i>Curcuma comosa</i> belongs to the Zingiberaceae family. In this study, two natural compounds were isolated from <i>C. comosa</i>, and their structures were determined using nuclear magnetic resonance. The isolated compounds were identified as 7-(3,4-dihydroxyphenyl)-5-hydroxy-1-phenyl-(1<i>E</i>)-1-heptene (<b>1</b>) and <i>trans</i>-1,7-diphenyl-5-hydroxy-1-heptene (<b>2</b>). Compound <b>1</b> showed the strongest cytotoxicity effect against HL-60 cells, while its antioxidant and anti-infla  ...[more]

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