A signature of tumor DNA repair genes associated with the prognosis of surgically-resected lung adenocarcinoma.

ABSTRACT:

Background

Lung cancer has the highest morbidity and mortality of cancers worldwide. Lung adenocarcinoma (LUAD) is the most common pathological subtype of lung cancer and surgery is its most common treatment. The dysregulated expression of DNA repair genes is found in a variety of cancers and has been shown to affect the origin and progression of these diseases. However, the function of DNA repair genes in surgically-treated LUAD is unclear.

Methods

We sought to determine the association between the signature of DNA repair genes for patients with surgical LUAD and their overall prognosis. We obtained gene expression data and corresponding clinical information of LUAD from The Cancer Genome Atlas (TCGA) database. The differently expressed DNA repair genes of surgically-treate

SUBMITTER: Yang X 

PROVIDER: S-EPMC7700735 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature