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Partial restoration of normal intestinal microbiota in morbidly obese women six months after bariatric surgery.


ABSTRACT: We studied the impact of bariatric surgery on the intestinal microbiota of morbidly obese study subjects. A total of 13 morbidly obese women (five of which had type 2 diabetes) and 14 healthy age- and gender-matched controls were recruited and the microbiota composition of fecal samples were determined by using a phylogenetic microarray. Sampling of the patients took place just one month before and 6 months after the operation. Within six months after bariatric surgery, the obese subjects had lost on average a quarter of their weight whereas four of the five of the diabetic subjects were in remission. Bariatric surgery was associated with an increased microbial community richness and Bacteroidetes/Firmicutes ratio. In addition, we observed an increased relative abundance of facultative anaerobes, such as Streptococcus spp., and a reduction in specific butyrate-producing Firmicutes. The observed postoperative alterations in intestinal microbiota reflect adaptation to the changing conditions in the gastrointestinal tract, such as energy restriction and the inability to process fiber-rich foods after bariatric surgery.

SUBMITTER: Koffert J 

PROVIDER: S-EPMC7700738 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Partial restoration of normal intestinal microbiota in morbidly obese women six months after bariatric surgery.

Koffert Jukka J   Lahti Leo L   Nylund Lotta L   Salminen Seppo S   Hannukainen Jarna C JC   Salminen Paulina P   de Vos Willem M WM   Nuutila Pirjo P  

PeerJ 20201126


We studied the impact of bariatric surgery on the intestinal microbiota of morbidly obese study subjects. A total of 13 morbidly obese women (five of which had type 2 diabetes) and 14 healthy age- and gender-matched controls were recruited and the microbiota composition of fecal samples were determined by using a phylogenetic microarray. Sampling of the patients took place just one month before and 6 months after the operation. Within six months after bariatric surgery, the obese subjects had lo  ...[more]

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