Ontology highlight
ABSTRACT:
SUBMITTER: Lung RW
PROVIDER: S-EPMC7701581 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Lung Raymond Wai-Ming RW Tong Joanna Hung-Man JH Ip Lok-Man LM Lam Ka-Hei KH Chan Anthony Wing-Hung AW Chak Wing-Po WP Chung Lau-Ying LY Yeung Walter Wai WW Hau Pok-Man PM Chau Shuk-Ling SL Tsao Sai-Wah SW Lau Kin-Mang KM Lo Kwok-Wai KW To Ka-Fai KF
Journal of cellular and molecular medicine 20201019 22
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated epithelial malignancy. The high expression of BART-miRNAs (miR-BARTs) during latent EBV infection in NPC strongly supports their pathological importance in cancer progression. Recently, we found that several BART-miRNAs work co-operatively to modulate the DNA damage response (DDR) by reducing Ataxia-telangiectasia-mutated (ATM) activity. In this study, we further investigated the role of miR-BARTs on DDR. The immunohistoche ...[more]