Ontology highlight
ABSTRACT:
SUBMITTER: Gang M
PROVIDER: S-EPMC7702478 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Gang Margery M Marin Nancy D ND Wong Pamela P Neal Carly C CC Marsala Lynne L Foster Mark M Schappe Timothy T Meng Wei W Tran Jennifer J Schaettler Maximilian M Davila Marco M Gao Feng F Cashen Amanda F AF Bartlett Nancy L NL Mehta-Shah Neha N Kahl Brad S BS Kim Miriam Y MY Cooper Matthew L ML DiPersio John F JF Berrien-Elliott Melissa M MM Fehniger Todd A TA
Blood 20201101 20
Natural killer (NK) cells are a promising cellular immunotherapy for cancer. Cytokine-induced memory-like (ML) NK cells differentiate after activation with interleukin-12 (IL-12), IL-15, and IL-18, exhibit potent antitumor responses, and safely induce complete remissions in patients with leukemia. However, many cancers are not fully recognized via NK cell receptors. Chimeric antigen receptors (CARs) have been used to enhance tumor-specific recognition by effector lymphocytes. We hypothesized tha ...[more]