KLF7: a new candidate biomarker and therapeutic target for high-grade serous ovarian cancer.

ABSTRACT:

Background

In spite of great progress in the surgical and clinical management, until now no significant improvement in overall survival of High-Grade Serous Ovarian Cancer (HGSOC) patients has been achieved. Important aspects for disease control remain unresolved, including unclear pathogenesis, high heterogeneity and relapse resistance after chemotherapy. Therefore, further research on molecular mechanisms involved in cancer progression are needed to find new targets for disease management. The Krüppel-like factors (KLFs) are a family of transcriptional regulators controlling several basic cellular processes, including proliferation, differentiation and migration. They have been shown to play a role in various cancer-relevant processes, in a context-dependent way.

Methods

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SUBMITTER: De Donato M 

PROVIDER: S-EPMC7702713 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature