Ontology highlight
ABSTRACT:
Availability and implementation: The VikNGS package can be downloaded at http://www.tcag.ca/tools/index.html.
Supplementary information: Supplementary data are available at Bioinformatics online.
SUBMITTER: Baskurt Z
PROVIDER: S-EPMC7703770 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Baskurt Zeynep Z Mastromatteo Scott S Gong Jiafen J Wintle Richard F RF Scherer Stephen W SW Strug Lisa J LJ
Bioinformatics (Oxford, England) 20200201 4
<h4>Summary</h4>Integration of next generation sequencing data (NGS) across different research studies can improve the power of genetic association testing by increasing sample size and can obviate the need for sequencing controls. If differential genotype uncertainty across studies is not accounted for, combining datasets can produce spurious association results. We developed the Variant Integration Kit for NGS (VikNGS), a fast cross-platform software package, to enable aggregation of several d ...[more]