Ontology highlight
ABSTRACT:
SUBMITTER: Liao P
PROVIDER: S-EPMC7703795 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Liao Peng P Bhattarai Nimisha N Cao Bo B Zhou Xiang X Jung Ji Hoon JH Damera Krishna K Fuselier Taylor T TT Thareja Suresh S Wimley William C WC Wang Binghe B Zeng Shelya X SX Lu Hua H
Biochemical and biophysical research communications 20200205 3
Post-translational modifications (PTMs) play pivotal roles in controlling the stability and activity of the tumor suppressor p53 in response to distinct stressors. Here we report an unexpected finding of a short chain fatty acid modification of p53 in human cells. Crotonic acid (CA) treatment induces p53 crotonylation, but surprisingly reduces its protein, but not mRNA level, leading to inhibition of p53 activity in a dose dependent fashion. Surprisingly this crotonylation targets serine 46, ins ...[more]