Ontology highlight
ABSTRACT:
SUBMITTER: Murphy MP
PROVIDER: S-EPMC7704061 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Murphy Matthew P MP Koepke Lauren S LS Lopez Michael T MT Tong Xinming X Ambrosi Thomas H TH Gulati Gunsagar S GS Marecic Owen O Wang Yuting Y Ransom Ryan C RC Hoover Malachia Y MY Steininger Holly H Zhao Liming L Walkiewicz Marcin P MP Quarto Natalina N Levi Benjamin B Wan Derrick C DC Weissman Irving L IL Goodman Stuart B SB Yang Fan F Longaker Michael T MT Chan Charles K F CKF
Nature medicine 20200817 10
Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive destruction of articular cartilage<sup>1</sup>. The etiology of OA is complex and involves a variety of factors, including genetic predisposition, acute injury and chronic inflammation<sup>2-4</sup>. Here we investigate the ability of resident skeletal stem-cell (SSC) populations to regenerate cartilage in relation to age, a possible contributor to the development of osteoarthritis<sup>5-7</sup>. We demonstrate ...[more]