Ontology highlight
ABSTRACT:
SUBMITTER: Aime M
PROVIDER: S-EPMC7704104 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Aime Mattia M Augusto Elisabete E Kouskoff Vladimir V Campelo Tiago T Martin Christelle C Humeau Yann Y Chenouard Nicolas N Gambino Frederic F
eLife 20201130
Survival depends on the ability of animals to select the appropriate behavior in response to threat and safety sensory cues. However, the synaptic and circuit mechanisms by which the brain learns to encode accurate predictors of threat and safety remain largely unexplored. Here, we show that frontal association cortex (FrA) pyramidal neurons of mice integrate auditory cues and basolateral amygdala (BLA) inputs non-linearly in a NMDAR-dependent manner. We found that the response of FrA pyramidal ...[more]