Identification of Circulating lncRNA Expression Profiles in Patients with Atrial Fibrillation.

ABSTRACT:

Purpose

To investigate the expression profiles of long noncoding RNAs (lncRNAs) in patients with atrial fibrillation (AF).

Methods

The peripheral blood monocytes of a total of 20 patients with AF and 20 healthy subjects were collected for gene chip technology to detect differentially expressed lncRNAs from 2017.01 to 2017.08. Reverse transcription polymerase chain reaction (RT-PCR) was applied for further verification. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to identify the functions of differentially expressed genes and related pathways.

Results

There were 19 lncRNAs differentially expressed (FC ≥ 2, P < 0.05), of which 6 were upregulated and 13 were downregulated. Two of three upregulated lncRNAs (P

SUBMITTER: Ruan ZB 

PROVIDER: S-EPMC7704132 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature