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Cellular and mitochondrial mechanisms of atrial fibrillation.


ABSTRACT: The molecular mechanisms underlying atrial fibrillation (AF), the most common form of arrhythmia, are poorly understood and therefore target-specific treatment options remain an unmet clinical need. Excitation-contraction coupling in cardiac myocytes requires high amounts of adenosine triphosphate (ATP), which is replenished by oxidative phosphorylation in mitochondria. Calcium (Ca2+) is a key regulator of mitochondrial function by stimulating the Krebs cycle, which produces nicotinamide adenine dinucleotide for ATP production at the electron transport chain and nicotinamide adenine dinucleotide phosphate for the elimination of reactive oxygen species (ROS). While it is now well established that mitochondrial dysfunction plays an important role in the pathophysiology of heart failure, this has been less investigated in atrial myocytes in AF. Considering the high prevalence of AF, investigating the role of mitochondria in this disease may guide the path towards new therapeutic targets. In this review, we discuss the importance of mitochondrial Ca2+ handling in regulating ATP production and mitochondrial ROS emission and how alterations, particularly in these aspects of mitochondrial activity, may play a role in AF. In addition to describing research advances, we highlight areas in which further studies are required to elucidate the role of mitochondria in AF.

SUBMITTER: Mason FE 

PROVIDER: S-EPMC7704501 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Cellular and mitochondrial mechanisms of atrial fibrillation.

Mason Fleur E FE   Pronto Julius Ryan D JRD   Alhussini Khaled K   Maack Christoph C   Voigt Niels N  

Basic research in cardiology 20201130 6


The molecular mechanisms underlying atrial fibrillation (AF), the most common form of arrhythmia, are poorly understood and therefore target-specific treatment options remain an unmet clinical need. Excitation-contraction coupling in cardiac myocytes requires high amounts of adenosine triphosphate (ATP), which is replenished by oxidative phosphorylation in mitochondria. Calcium (Ca<sup>2+</sup>) is a key regulator of mitochondrial function by stimulating the Krebs cycle, which produces nicotinam  ...[more]

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