Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC7704619 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Li Jianzhong J Yang Youjing Y Wei Shuhui S Chen Ling L Xue Lian L Tian Hailin H Tao Shasha S
Frontiers in cell and developmental biology 20201117
Bixin, a natural carotenoid extracted from the seeds of <i>Bixa orellana</i>, has antioxidant and anti-inflammation effects. However, the pharmacological effects and underlying mechanisms of bixin in kidney interstitial fibrosis remain unknown. Partial epithelial-to-mesenchymal transition (EMT) of tubular cells has been linked to renal interstitial fibrosis. Here, we found that in the unilateral ureteral obstruction model, bixin administration could ameliorate kidney interstitial fibrosis. The e ...[more]