Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations.

ABSTRACT: Detection of Identical-By-Descent (IBD) segments provides a fundamental measure of genetic relatedness and plays a key role in a wide range of analyses. We develop FastSMC, an IBD detection algorithm that combines a fast heuristic search with accurate coalescent-based likelihood calculations. FastSMC enables biobank-scale detection and dating of IBD segments within several thousands of years in the past. We apply FastSMC to 487,409 UK Biobank samples and detect ~214 billion IBD segments transmitted by shared ancestors within the past 1500 years, obtaining a fine-grained picture of genetic relatedness in the UK. Sharing of common ancestors strongly correlates with geographic distance, enabling the use of genomic data to localize a sample's birth coordinates with a median error of 45 km. We

SUBMITTER: Nait Saada J 

PROVIDER: S-EPMC7704644 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature