Zinc regulates primary ovarian tumor growth and metastasis through the epithelial to mesenchymal transition.

ABSTRACT:

Background

The trace element zinc plays an indispensable role in human health and diseases including cancer due to its antioxidant properties. While zinc supplements have been used for cancer prevention, zinc is also a risk factor for cancer development. It is still unclear how zinc plays a role in ovarian cancer.

Methods

To understand how zinc contributes to ovarian tumor growth and metastasis, we examined whether zinc contributes to tumor metastasis by regulating epithelial to mesenchymal transition (EMT) using ovarian cancer cells in vitro. Cell migration and invasion were examined using transwell plates and EMT markers were examined using Western blot. Primary ovarian tumor growth and metastasis were assessed using orthotopic ovarian cancer mouse models in vivo.

Resul

SUBMITTER: Zhang R 

PROVIDER: S-EPMC7704937 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature