Ontology highlight
ABSTRACT:
SUBMITTER: Grigsby KB
PROVIDER: S-EPMC7705291 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Grigsby Kolter B KB Savarese Antonia M AM Metten Pamela P Mason Barbara J BJ Blednov Yuri A YA Crabbe John C JC Ozburn Angela R AR
Neuroscience insights 20201125
High Drinking in the Dark (HDID-1) mice represent a unique genetic risk model of binge-like drinking and a novel means of screening potential pharmacotherapies to treat alcohol use disorders (AUDs). We tested the effects of tacrolimus (0, 0.5, 1, and 2 mg/kg), sirolimus (0, 5, 10, and 20 mg/kg), palmitoylethanolamide (PEA; 0, 75, 150, and 225 mg/kg), and secukinumab (0, 5, 20, and 60 mg/kg) on binge-like ethanol intake (2-day, "Drinking in the Dark" [DID]) and blood alcohol levels (BALs) in HDID ...[more]