Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury.
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ABSTRACT:
SUBMITTER: Wu D
PROVIDER: S-EPMC7705672 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury.
Wu Di D Jin Ying Y Shapiro Tatiana M TM Hinduja Abhishek A Baas Peter W PW Tom Veronica J VJ
Nature communications 20201130 1
After a dorsal root crush injury, centrally-projecting sensory axons fail to regenerate across the dorsal root entry zone (DREZ) to extend into the spinal cord. We find that chemogenetic activation of adult dorsal root ganglion (DRG) neurons improves axon growth on an in vitro model of the inhibitory environment after injury. Moreover, repeated bouts of daily chemogenetic activation of adult DRG neurons for 12 weeks post-crush in vivo enhances axon regeneration across a chondroitinase-digested D ...[more]
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