Ontology highlight
ABSTRACT:
SUBMITTER: Lawlor K
PROVIDER: S-EPMC7706704 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Lawlor Katerina K Marques-Torrejon Maria Angeles MA Dharmalingham Gopuraja G El-Azhar Yasmine Y Schneider Michael D MD Pollard Steven M SM Rodríguez Tristan A TA
Genes & development 20201112 23-24
There is increasing evidence demonstrating that adult neural stem cells (NSCs) are a cell of origin of glioblastoma. Here we analyzed the interaction between transformed and wild-type NSCs isolated from the adult mouse subventricular zone niche. We found that transformed NSCs are refractory to quiescence-inducing signals. Unexpectedly, we also demonstrated that these cells induce quiescence in surrounding wild-type NSCs in a cell-cell contact and Notch signaling-dependent manner. Our findings th ...[more]