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Glioblastoma stem cells induce quiescence in surrounding neural stem cells via Notch signaling.


ABSTRACT: There is increasing evidence demonstrating that adult neural stem cells (NSCs) are a cell of origin of glioblastoma. Here we analyzed the interaction between transformed and wild-type NSCs isolated from the adult mouse subventricular zone niche. We found that transformed NSCs are refractory to quiescence-inducing signals. Unexpectedly, we also demonstrated that these cells induce quiescence in surrounding wild-type NSCs in a cell-cell contact and Notch signaling-dependent manner. Our findings therefore suggest that oncogenic mutations are propagated in the stem cell niche not just through cell-intrinsic advantages, but also by outcompeting neighboring stem cells through repression of their proliferation.

SUBMITTER: Lawlor K 

PROVIDER: S-EPMC7706704 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Glioblastoma stem cells induce quiescence in surrounding neural stem cells via Notch signaling.

Lawlor Katerina K   Marques-Torrejon Maria Angeles MA   Dharmalingham Gopuraja G   El-Azhar Yasmine Y   Schneider Michael D MD   Pollard Steven M SM   Rodríguez Tristan A TA  

Genes & development 20201112 23-24


There is increasing evidence demonstrating that adult neural stem cells (NSCs) are a cell of origin of glioblastoma. Here we analyzed the interaction between transformed and wild-type NSCs isolated from the adult mouse subventricular zone niche. We found that transformed NSCs are refractory to quiescence-inducing signals. Unexpectedly, we also demonstrated that these cells induce quiescence in surrounding wild-type NSCs in a cell-cell contact and Notch signaling-dependent manner. Our findings th  ...[more]

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