Dataset Information

Prophylactic total pancreatectomy in individuals at high risk of pancreatic ductal adenocarcinoma (PROPAN): systematic review and shared decision-making programme using decision tables.

ABSTRACT: Background: Individuals with a very high lifetime risk of developing pancreatic ductal adenocarcinoma; for example, hereditary pancreatitis and main-duct or mixed-type intraductal papillary mucinous neoplasm, may wish to discuss prophylactic total pancreatectomy but strategies to do so are lacking.

Objective: To develop a shared decision-making programme for prophylactic total pancreatectomy using decision tables.

Methods: Focus group meetings with patients were used to identify relevant questions. Systematic reviews were performed to answer these questions.

Results: The first tables included hereditary pancreatitis and main-duct or mixed-type intraductal papillary mucinous neoplasm. No studies focused on prophylactic total pancreatectomy in these groups. In 52 studies (3570 patients), major morbidity after total pancreatectomy was 25% and 30-day mortality was 6%. After minimally invasive total pancreatectomy (seven studies, 35 patients) this was, respectively, 13% and 0%. Exocrine insufficiency-related symptoms occurred in 33%. Quality of life after total pancreatectomy was slightly lower compared with the general population.

Conclusion: The decision tables can be helpful for discussing prophylactic total pancreatectomy with individuals at high risk of pancreatic ductal adenocarcinoma.

SUBMITTER: Scholten L

PROVIDER: S-EPMC7707864 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Prophylactic total pancreatectomy in individuals at high risk of pancreatic ductal adenocarcinoma (PROPAN): systematic review and shared decision-making programme using decision tables.

Scholten Lianne L Latenstein Anouk Ej AE Aalfs Cora M CM Bruno Marco J MJ Busch Olivier R OR Bonsing Bert A BA Koerkamp Bas Groot BG Molenaar I Quintus IQ Ubbink Dirk T DT van Hooft Jeanin E JE Fockens Paul P Glas Jolanda J DeVries J Hans JH Besselink Marc G MG

United European gastroenterology journal 20200723 8

<h4>Background</h4>Individuals with a very high lifetime risk of developing pancreatic ductal adenocarcinoma; for example, hereditary pancreatitis and main-duct or mixed-type intraductal papillary mucinous neoplasm, may wish to discuss prophylactic total pancreatectomy but strategies to do so are lacking.<h4>Objective</h4>To develop a shared decision-making programme for prophylactic total pancreatectomy using decision tables.<h4>Methods</h4>Focus group meetings with patients were used to identi ...[more]

PMID: 32703081

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Dataset Information

Prophylactic total pancreatectomy in individuals at high risk of pancreatic ductal adenocarcinoma (PROPAN): systematic review and shared decision-making programme using decision tables.

Publications

Prophylactic total pancreatectomy in individuals at high risk of pancreatic ductal adenocarcinoma (PROPAN): systematic review and shared decision-making programme using decision tables.

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