Ontology highlight
ABSTRACT:
SUBMITTER: Ryu HY
PROVIDER: S-EPMC7708062 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Ryu Hong-Yeoul HY Zhao Dejian D Li Jianhui J Su Dan D Hochstrasser Mark M
Nucleic acids research 20201201 21
Histones are substrates of the SUMO (small ubiquitin-like modifier) conjugation pathway. Several reports suggest histone sumoylation affects transcription negatively, but paradoxically, our genome-wide analysis shows the modification concentrated at many active genes. We find that trans-tail regulation of histone-H2B ubiquitylation and H3K4 di-methylation potentiates subsequent histone sumoylation. Consistent with the known control of the Set3 histone deacetylase complex (HDAC) by H3K4 di-methyl ...[more]