Cancer-Specific Mortality, All-Cause Mortality, and Overdiagnosis in Lung Cancer Screening Trials: A Meta-Analysis.

ABSTRACT:

Purpose

Benefit of lung cancer screening using low-dose computed tomography (LDCT) in reducing lung cancer-specific and all-cause mortality is unclear. We undertook a meta-analysis to assess its associations with outcomes.

Methods

We searched the literature and previous systematic reviews to identify randomized controlled trials comparing LDCT screening with usual care or chest radiography. We performed meta-analysis using a random effects model. The primary outcomes were lung cancer-specific mortality, all-cause mortality, and the cumulative incidence ratio of lung cancer between screened and unscreened groups as a measure of overdiagnosis.

Results

Meta-analysis was based on 8 trials with 90,475 patients that had a low risk of bias. There was a significant reduction

SUBMITTER: Ebell MH 

PROVIDER: S-EPMC7708293 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature