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Author Correction: Intact glycosphingolipidomic analysis of the cell membrane during differentiation yields extensive glycan and lipid changes.

ABSTRACT: An amendment to this paper has been published and can be accessed via a link at the top of the paper.

SUBMITTER: Wong M

PROVIDER: S-EPMC7708974 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Author Correction: Intact glycosphingolipidomic analysis of the cell membrane during differentiation yields extensive glycan and lipid changes.

Wong Maurice M Xu Gege G Park Dayoung D Barboza Mariana M Lebrilla Carlito B CB

Scientific reports 20201201 1

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...[more]

PMID: 33262440

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Intact glycosphingolipidomic analysis of the cell membrane during differentiation yields extensive glycan and lipid changes.

Project description:Glycosphingolipids (GSLs) are found in cellular membranes of most organisms and play important roles in cell-cell recognition, signaling, growth, and adhesion, among others. A method based on nanoflow high performance liquid chromatography-chip-quadrupole-time-of-flight mass spectrometry (nanoHPLC Chip-Q-TOF MS) was applied towards identifying and quantifying intact GSLs from a variety of samples, including cultured cell lines and animal tissue. The method provides the composition and sequence of the glycan, as well as variations in the ceramide portion of the GSL. It was used to profile the changes in the glycolipidome of Caco-2 cells as they undergo differentiation. A total of 226 unique GSLs were found among Caco-2 samples from five differentiation time-points. The method provided a comprehensive glycolipidomic profile of a cell during differentiation to yield the dynamic variation of intact GSL structures.

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Author Correction: Circularized fluorescent nanodiscs for probing protein-lipid interactions.