Ontology highlight
ABSTRACT:
SUBMITTER: Laing E
PROVIDER: S-EPMC7709164 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Research square 20201124
Sensitive and specific SARS-CoV-2 antibody assays remain critical for community and hospital-based SARS-CoV-2 surveillance. Here, we developed and applied a multiplex microsphere-based immunoassay (MMIA) for COVD-19 antibody studies that incorporates spike protein trimers of SARS-CoV-2, SARS-CoV-1, MERS-CoV, and the seasonal human betacoronaviruses, HCoV-HKU1 and HCoV-OC43, that enables measurement of off-target pre-existing cross-reactive antibodies. The MMIA performances characteristics are: 9 ...[more]