Ontology highlight
ABSTRACT:
SUBMITTER: Tan Z
PROVIDER: S-EPMC7710122 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Tan Zengqi Z Cao Lin L Wu Yurong Y Wang Bowen B Song Zhihui Z Yang Juhong J Cheng Lanming L Yang Xiaomin X Zhou Xiaoman X Dai Zhijun Z Li Xiang X Guan Feng F
Journal of extracellular vesicles 20201030 1
Small extracellular vesicles (sEVs) are enriched in glycoconjugates and display specific glycosignatures. Aberrant expression of surface glycoconjugates is closely correlated with cancer progression and metastasis. The essential functions of glycoconjugates in sEVs are poorly understood. In this study, we observed significantly reduced levels of bisecting GlcNAc in breast cancer. Introduction of bisecting GlcNAc into breast cancer cells altered the bisecting GlcNAc status on sEVs, and sEVs with ...[more]