Ontology highlight
ABSTRACT:
SUBMITTER: Coit P
PROVIDER: S-EPMC7710270 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Coit Patrick P Ortiz-Fernandez Lourdes L Lewis Emily E EE McCune W Joseph WJ Maksimowicz-McKinnon Kathleen K Sawalha Amr H AH
JCI insight 20201119 22
Epigenetic dysregulation is implicated in the pathogenesis of lupus. We performed a longitudinal analysis to assess changes in DNA methylation in lupus neutrophils over 4 years of follow-up and across disease activity levels using 229 patient samples. We demonstrate that DNA methylation profiles in lupus are partly determined by ancestry-associated genetic variations and are highly stable over time. DNA methylation levels in 2 CpG sites correlated significantly with changes in lupus disease acti ...[more]