Ontology highlight
ABSTRACT:
SUBMITTER: Fischinger S
PROVIDER: S-EPMC7710302 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Fischinger Stephanie S Dolatshahi Sepideh S Jennewein Madeleine F MF Rerks-Ngarm Supachai S Pitisuttithum Punnee P Nitayaphan Sorachai S Michael Nelson N Vasan Sandhya S Ackerman Margaret E ME Streeck Hendrik H Alter Galit G
JCI insight 20201105 21
While the RV144 HIV vaccine trial led to moderately reduced risk of HIV acquisition, emerging data from the HVTN702 trial point to the critical need to reexamine RV144-based correlates of reduced risk of protection. While in RV144, the induction of V2-binding, non-IgA, IgG3 antibody responses with nonneutralizing functions were linked to reduced risk of infection, the interactions between these signatures remain unclear. Thus, here we comprehensively profile the humoral immune response in 300 RV ...[more]