Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders.
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ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC7710361 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders.
Yang Jian J Zheng Peng P Li Yifan Y Wu Jing J Tan Xunmin X Zhou Jingjing J Sun Zuoli Z Chen Xu X Zhang Guofu G Zhang Hanping H Huang Yu Y Chai Tingjia T Duan Jiajia J Liang Weiwei W Yin Bangmin B Lai Jianbo J Huang Tingting T Du Yanli Y Zhang Peifen P Jiang Jiajun J Xi Caixi C Wu Lingling L Lu Jing J Mou Tingting T Xu Yi Y Perry Seth W SW Wong Ma-Li ML Licinio Julio J Hu Shaohua S Hu Shaohua S Wang Gang G Xie Peng P
Science advances 20201202 49
Gut microbiome disturbances have been implicated in major depressive disorder (MDD). However, little is known about how the gut virome, microbiome, and fecal metabolome change, and how they interact in MDD. Here, using whole-genome shotgun metagenomic and untargeted metabolomic methods, we identified 3 bacteriophages, 47 bacterial species, and 50 fecal metabolites showing notable differences in abundance between MDD patients and healthy controls (HCs). Patients with MDD were mainly characterized ...[more]
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