Ontology highlight
ABSTRACT:
SUBMITTER: Rocha AL
PROVIDER: S-EPMC7710362 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Rocha Andréa Livia AL de Lima Tanes Imamura TI de Souza Gerson Profeta GP Corrêa Renan Oliveira RO Ferrucci Danilo Lopes DL Rodrigues Bruno B Lopes-Ramos Camila C Nilsson Daniel D Knittel Thiago Leite TL Castro Pollyana Ribeiro PR Fernandes Mariane Font MF Dos Santos Martins Flaviano F Parmigiani Raphael Bessa RB Silveira Leonardo Reis LR Carvalho Hernandes F HF Auwerx Johan J Vinolo Marco Aurélio R MAR Boucher Jeremie J Mori Marcelo A MA
Science advances 20201202 49
MicroRNAs (miRNAs) have been implicated in oxidative metabolism and brown/beige adipocyte identity. Here, we tested whether widespread changes in miRNA expression promoted by treatment with the small-molecule enoxacin cause browning and prevent obesity. Enoxacin mitigated diet-induced obesity in mice, and this was associated with increased energy expenditure. Consistently, subcutaneous white and brown adipose tissues and skeletal muscle of enoxacin-treated mice had higher levels of markers assoc ...[more]