Dataset Information

The effect of a mobile HEPA filter system on 'infectious' aerosols, sound and air velocity in the SenseLab.

ABSTRACT: High efficiency air filtration has been suggested to reduce airborne transmission of 'infectious' aerosols. In this study the 'air cleaning' effect as well as the effect on sound and air velocity (draught risk) of a mobile High-Efficiency Particulate Air (HEPA) filter system was tested for different settings and positions in the Experience room of the SenseLab. From both the noise assessments by a panel of subjects and sound monitoring it was concluded that the mobile HEPA filter system causes an unacceptable background sound level in the tested classroom setting (Experience room). With respect to the air velocity measurements and draught rating calculations, it was concluded that both depend on the position and the setting of the HEPA filter system as well as on the position and height of the measurements. For the removal of aerosols simulated by air-filled soap bubbles in front of the subject, the mobile HEPA filter system performed better as compared to the 'No ventilation' regime, for all settings and both positions, and for some settings, even better than all the tested mixing ventilation regimes. The use of a mobile HEPA filter system seems a good additional measure when only natural ventilation options are available. Future research should focus on rooms of different sizes or shapes, as this may also play a role in the filter's performance, noise and draught effects.

SUBMITTER: Bluyssen PM

PROVIDER: S-EPMC7711180 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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The effect of a mobile HEPA filter system on 'infectious' aerosols, sound and air velocity in the SenseLab.

Bluyssen Philomena M PM Ortiz Marco M Zhang Dadi D

Building and environment 20201203

High efficiency air filtration has been suggested to reduce airborne transmission of 'infectious' aerosols. In this study the 'air cleaning' effect as well as the effect on sound and air velocity (draught risk) of a mobile High-Efficiency Particulate Air (HEPA) filter system was tested for different settings and positions in the Experience room of the SenseLab. From both the noise assessments by a panel of subjects and sound monitoring it was concluded that the mobile HEPA filter system causes a ...[more]

PMID: 33293755

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Project description:BackgroundDevelopmental exposure to particulate matter (PM) air pollution may impair children's behaviors. Our objectives were to quantify the impact of reducing indoor PM using portable HEPA filter air cleaners during pregnancy on behavioral problems in children and to assess associations between indoor fine PM (PM2.5) concentrations during pregnancy and children's behavior.MethodsThis is a secondary analysis of a single-blind parallel-group randomized controlled trial in which we randomly assigned 540 non-smoking pregnant women to receive 1 or 2 HEPA filter air cleaners or no air cleaners. We administered the Behavior Assessment System for Children (BASC-3) to caregivers when children were a mean age of 23 months, and again at a mean age of 48 months. Primary outcomes were the four BASC-3 composite scales: externalizing problems, internalizing problems, adaptive skills, and the behavioral symptoms index. We imputed missing data using multiple imputation with chained equations. The primary analysis was by intention-to-treat. In a secondary analysis, we evaluated associations between BASC-3 composite indices and modeled trimester-specific PM2.5 concentrations inside residences.ResultsWe enrolled participants at a median of 11 weeks gestation. After excluding miscarriages, still births and neonatal deaths, our analysis included 478 children (233 control and 245 intervention). We observed no differences in the mean BASC-3 scores between treatment groups. An interquartile increase (20.1 µg/m3) in first trimester PM2.5 concentration was associated with higher externalizing problem scores (2.4 units, 95% CI: 0.7, 4.1), higher internalizing problem scores (2.4 units, 95% CI: 0.7, 4.0), lower adaptive skills scores (-1.5 units, 95% CI: -3.0, 0.0), and higher behavior symptoms index scores (2.3 units, 95% CI: 0.7, 3.9). Third trimester PM2.5 concentrations were also associated with some behavioral indices at age 4, but effect estimates were smaller. No significant associations were observed with PM2.5 concentrations during the second trimester or for any of the BASC indices when children were 2 years old.ConclusionWe found no benefit of reducing indoor particulate air pollution during pregnancy on parent-reported behaviors in children. Associations between indoor PM2.5 concentrations in the first trimester and behavioral scores among 4-year old children suggest that it may be necessary to intervene early in pregnancy to protect children, but these exploratory findings should be interpreted cautiously.Trial registrationClinicalTrials.gov: NCT01741051.

Project description:BackgroundThe role of portable high-efficiency particulate air (HEPA) filters for supplemental aerosol mitigation during exercise testing is unknown and might be relevant during COVID-19 pandemic.Research questionWhat is the effect of portable HEPA filtering on aerosol concentration during exercise testing and its efficiency in reducing room clearance time in a clinical exercise testing laboratory?Study design and methodsSubjects were six healthy volunteers aged 20 to 56 years. In the first experiment, exercise was performed in a small tent with controlled airflow with the use of a stationary cycle, portable HEPA filter with fume hood, and particle counter to document aerosol concentration. Subjects performed a four-stage maximal exercise test that lasted 12 min plus 5 min of pretest quiet breathing and 3 min of active recovery. First, they exercised without mitigation then with portable HEPA filter running. In a separate experiment, room aerosol clearance time was measured in a clinical exercise testing laboratory by filling it with artificially generated aerosols and measuring time to 99.9% aerosol clearance with heating, ventilation, and air conditioning (HVAC) only or HVAC plus portable HEPA filter running.ResultsIn the exercise experiment, particle concentrations reached 1,722 ± 1,484/L vs 96 ± 124/L (P < .04) for all particles (>0.3 μm), 1,339 ± 1,281/L vs 76 ± 104/L (P < .05) for smaller particles (0.3 to 1.0 μm), and 333 ± 209/L vs 17 ± 19/L (P < .01) for larger particles (1.0 to 5.0 μm) at the end of the protocol in a comparison of mitigation vs portable HEPA filter. Use of a portable HEPA filter in a clinical exercise laboratory clearance experiment reduced aerosol clearance time 47% vs HVAC alone.InterpretationThe portable HEPA filter reduced the concentration of aerosols generated during exercise testing by 96% ± 2% for all particle sizes and reduced aerosol room clearance time in clinical exercise testing laboratories. Portable HEPA filters therefore might be useful in clinical exercise testing laboratories to reduce the risk of COVID-19 transmission.

Dataset Information

The effect of a mobile HEPA filter system on 'infectious' aerosols, sound and air velocity in the SenseLab.

Publications

The effect of a mobile HEPA filter system on 'infectious' aerosols, sound and air velocity in the SenseLab.

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