New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.
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ABSTRACT:
SUBMITTER: Evangelou E
PROVIDER: S-EPMC7711277 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
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New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.
Evangelou Evangelos E Gao He H Chu Congying C Ntritsos Georgios G Blakeley Paul P Butts Andrew R AR Pazoki Raha R Suzuki Hideaki H Koskeridis Fotios F Yiorkas Andrianos M AM Karaman Ibrahim I Elliott Joshua J Luo Qiang Q Aeschbacher Stefanie S Bartz Traci M TM Baumeister Sebastian E SE Braund Peter S PS Brown Michael R MR Brody Jennifer A JA Clarke Toni-Kim TK Dimou Niki N Faul Jessica D JD Homuth Georg G Jackson Anne U AU Kentistou Katherine A KA Joshi Peter K PK Lemaitre Rozenn N RN Lind Penelope A PA Lyytikäinen Leo-Pekka LP Mangino Massimo M Milaneschi Yuri Y Nelson Christopher P CP Nolte Ilja M IM Perälä Mia-Maria MM Polasek Ozren O Porteous David D Ratliff Scott M SM Smith Jennifer A JA Stančáková Alena A Teumer Alexander A Tuominen Samuli S Thériault Sébastien S Vangipurapu Jagadish J Whitfield John B JB Wood Alexis A Yao Jie J Yu Bing B Zhao Wei W Arking Dan E DE Auvinen Juha J Liu Chunyu C Männikkö Minna M Risch Lorenz L Rotter Jerome I JI Snieder Harold H Veijola Juha J Blakemore Alexandra I AI Boehnke Michael M Campbell Harry H Conen David D Eriksson Johan G JG Grabe Hans J HJ Guo Xiuqing X van der Harst Pim P Hartman Catharina A CA Hayward Caroline C Heath Andrew C AC Jarvelin Marjo-Riitta MR Kähönen Mika M Kardia Sharon L R SLR Kühne Michael M Kuusisto Johanna J Laakso Markku M Lahti Jari J Lehtimäki Terho T McIntosh Andrew M AM Mohlke Karen L KL Morrison Alanna C AC Martin Nicholas G NG Oldehinkel Albertine J AJ Penninx Brenda W J H BWJH Psaty Bruce M BM Raitakari Olli T OT Rudan Igor I Samani Nilesh J NJ Scott Laura J LJ Spector Tim D TD Verweij Niek N Weir David R DR Wilson James F JF Levy Daniel D Tzoulaki Ioanna I Bell Jimmy D JD Matthews Paul M PM Rothenfluh Adrian A Desrivières Sylvane S Schumann Gunter G Elliott Paul P
Nature human behaviour 20190729 9
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d<sup>-1</sup>) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol int ...[more]
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