Association of Recent Stressful Life Events With Mental and Physical Health in the Context of Genomic and Exposomic Liability for Schizophrenia.

ABSTRACT:

Importance

Both adulthood stressful life events (SLEs) and liability for schizophrenia have been associated with poor mental and physical health in the general population, but their interaction remains to be elucidated to improve population-based health outcomes.

Objective

To test whether recent SLEs interact with genetic and environmental liability for schizophrenia in models of mental and physical health.

Design, setting, and participants

The Netherlands Mental Health Survey and Incidence Study-2 is a population-based prospective cohort study designed to investigate the prevalence, incidence, course, and consequences of mental disorders in the Dutch general population. Participants were enrolled from November 5, 2007, to July 31, 2009, and followed up with 3 assessm

SUBMITTER: Pries LK 

PROVIDER: S-EPMC7711318 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature