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Sex Differences in Time-Series Changes in Pseudo-R² Values Regarding Hyperuricemia in Relation to the Kidney Prognosis.

ABSTRACT: Studies on sex differences in time-series changes in pseudo-R² values regarding hyperuricemia (HU) in relation to the kidney prognosis among patients with chronic kidney disease (CKD) are scant. The kidney prognosis was evaluated in 200 patients with CKD (median follow-up, 12.3 years). Survival analyses and logistic regression analyses were conducted, generating time-series pseudo-R² values. We used four definitions of HU according to serum uric acid (SUA) levels (HU6, SUA ? 6.0 mg/dL; HU7, SUA ? 7.0 mg/dL; HU8, SUA ? 8.0 mg/dL) and antihyperuricemic agent use to calculate the mean and percentage of the change in pseudo-R² values from the 6th year until the end of the study (6Y-End Mean and 6Y-End Change, respectively). The multivariable Cox regression analysis showed that HU7 was significantly associated with kidney outcomes. When stratified by sex, the 6Y-End Mean was clearly higher in women than in men for all HU definitions, with the highest value (0.1755) obtained for HU7 in women. The pseudo-R² values for HU6 in women showed an increasing pattern, with a 6Y-End Change of 11.4%/year. Thus, it may be clinically meaningful to consider sex differences in the time-series pseudo-R² values regarding HU and kidney outcomes.

SUBMITTER: Kataoka H

PROVIDER: S-EPMC7711484 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Sex Differences in Time-Series Changes in Pseudo-R2 Values Regarding Hyperuricemia in Relation to the Kidney Prognosis.

Kataoka Hiroshi H Ohara Mamiko M Mochizuki Toshio T Iwadoh Kazuhiro K Ushio Yusuke Y Kawachi Keiko K Watanabe Kentaro K Watanabe Saki S Akihisa Taro T Makabe Shiho S Manabe Shun S Sato Masayo M Iwasa Naomi N Yoshida Rie R Sawara Yukako Y Hanafusa Norio N Tsuchiya Ken K Nitta Kosaku K

Journal of personalized medicine 20201126 4

Studies on sex differences in time-series changes in pseudo-R2 values regarding hyperuricemia (HU) in relation to the kidney prognosis among patients with chronic kidney disease (CKD) are scant. The kidney prognosis was evaluated in 200 patients with CKD (median follow-up, 12.3 years). Survival analyses and logistic regression analyses were conducted, generating time-series pseudo-R2 values. We used four definitions of HU according to serum uric acid (SUA) lev ...[more]

PMID: 33256045

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Project description:BackgroundAlthough obesity is a well-known risk factor for hyperuricemia, it remains unclear whether obese subjects with metabolically healthy status have a decreased the risk of hyperuricemia and whether sex modifies the association of metabolically healthy obesity (MHO) with hyperuricemia risk. We aimed to investigate the sex-specific association between MHO and other obesity phenotypes and hyperuricemia, and to use Bayesian networks to determine and visualize the interactions among hyperuricemia and its related factors.MethodsThis study was conducted using data from the China Health and Nutrition Survey 2009. Hyperuricemia was defined as serum uric acid ≥ 420 μmol/L in men and ≥ 360 μmol/L in women according to the guidelines. Body mass index (BMI) was used to define normal weight, overweight, and obese status in subjects, and metabolic health state was defined by the Adult Treatment Panel (ATP)-III and Visceral Adiposity Index (VAI) criteria, respectively. Subjects were categorized into six phenotypes according to their metabolic health and BMI level status.ResultsOf the 7,364 Chinese adult individuals included, the prevalence of hyperuricemia among MHO women was only 8.5% (95% CI 4.8 to 14.3%), but increased to 30.7% among MUO women, whereas the highest prevalence among men was found in the MUOW phenotype (39.4%, 95% CI 35.4 to 43.6%), compared to 15.4% for male subjects with MHO. After adjusting for confounders, the MHO phenotype was significantly associated with an increased risk of hyperuricemia compared with their MHNW counterparts in women (OR: 1.95, 95% CI: 1.02-3.74) whereas a significant association was not found in men (OR: 1.46, 95% CI: 0.8-2.68). A complex network structure was established by BNs and then used to find connections between hyperuricemia and its related factors, as well as their interrelationships. By using BN reasoning, the probability of having hyperuricemia was 0.076 among MHO men, while it reached 0.124 in MHO women.ConclusionsIn conclusion, our results demonstrated that the MHO phenotype was significantly associated with the risk of hyperuricemia only in women, not in men. This sex-specific differences in the association may suggest a favorable condition of MHO for Chinese men with respect to hyperuricemia risk, meanwhile more attention should be paid to the increased risk of hyperuricemia among MHO women.

Dataset Information

Sex Differences in Time-Series Changes in Pseudo-R² Values Regarding Hyperuricemia in Relation to the Kidney Prognosis.

Publications

Sex Differences in Time-Series Changes in Pseudo-<i>R</i><sup>2</sup> Values Regarding Hyperuricemia in Relation to the Kidney Prognosis.

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