Ontology highlight
ABSTRACT:
SUBMITTER: Le Louedec F
PROVIDER: S-EPMC7712135 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Le Louedec Félicien F Leenhardt Fanny F Marin Clémence C Chatelut Étienne É Evrard Alexandre A Ciccolini Joseph J
Vaccines 20201031 4
Immune check-point inhibitors are drugs that are markedly different from other anticancer drugs because of their indirect mechanisms of antitumoral action and their apparently random effect in terms of efficacy and toxicity. This marked pharmacodynamics variability in patients calls for reconsidering to what extent approved dosing used in clinical practice are optimal or whether they should require efforts for customization in outlier patients. To better understand whether or not dosing could be ...[more]