The "Little Iron Waltz": The Ternary Response of Paracoccidioides spp. to Iron Deprivation.
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ABSTRACT:
SUBMITTER: de Souza AF
PROVIDER: S-EPMC7712450 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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The "Little Iron Waltz": The Ternary Response of <i>Paracoccidioides</i> spp. to Iron Deprivation.
de Souza Aparecido Ferreira AF de Paula Marcella Silva MS Lima Raisa Melo RM Silva Marielle Garcia MG de Curcio Juliana Santana JS Pereira Maristela M de Almeida Soares Célia Maria CM
Journal of fungi (Basel, Switzerland) 20201012 4
<i>Paracoccidioides</i> is a genus of thermodimorphic fungi that causes paracoccidioidomycosis. When in the host, the fungus undergoes several challenges, including iron deprivation imposed by nutritional immunity. In response to the iron deprivation triggered by the host, the fungus responds in a ternary manner using mechanisms of high affinity and specificity for the uptake of Fe, namely non-classical reductive iron uptake pathway, uptake of host iron proteins, and biosynthesis and uptake of s ...[more]
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