Ontology highlight
ABSTRACT:
SUBMITTER: Bhattacharya A
PROVIDER: S-EPMC7712490 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Bhattacharya Antaripa A Izzo Antonella A Mollo Nunzia N Napolitano Filomena F Limone Adriana A Margheri Francesca F Mocali Alessandra A Minopoli Giuseppina G Lo Bianco Alessandra A Di Maggio Federica F D'Argenio Valeria V Montuori Nunzia N Lavecchia Antonio A Sarnataro Daniela D
Journal of personalized medicine 20201116 4
Alzheimer's disease (AD) is a fatal neurodegenerative disorder caused by protein misfolding and aggregation, affecting brain function and causing dementia. Amyloid beta (Aβ), a peptide deriving from amyloid precursor protein (APP) cleavage by-and γ-secretases, is considered a pathological hallmark of AD. Our previous study, together with several lines of evidence, identified a strict link between APP, Aβ and 37/67kDa laminin receptor (LR), finding the possibility to regulate intracellular APP lo ...[more]