Ontology highlight
ABSTRACT:
SUBMITTER: Kuiper BD
PROVIDER: S-EPMC7712628 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Kuiper Benjamin D BD Slater Kristin K Spellmon Nicholas N Holcomb Joshua J Medapureddy Prasanna P Muzzarelli Kendall M KM Yang Zhe Z Ovadia Reuben R Amblard Franck F Kovari Iulia A IA Schinazi Raymond F RF Kovari Ladislau C LC
Biochemical and biophysical research communications 20170322 4
Zika virus (ZIKV) is a flavivirus spread by daytime-active Aedes spp. mosquitoes such as A. aegypti and A. albopictus. Previously thought to be a mild infection, the latest ZIKV outbreak in the Americas is causally associated with more severe symptoms as well as severe birth defects, such as microcephaly. Currently no vaccine or antiviral exists. However, recent progress has demonstrated the viral NS2B/NS3 protease may be a suitable target for the development of small-molecule antiviral agents. ...[more]